If we’re talking real-life studies rather than simulation exercises, there are a few published studies in pharmacometrics that I’m aware of that utilised optimal design. But I’m not sure if any actually compare different optimal design methods. The closest is probably Green & Duffull , who compared an “empirical” design with a D-optimal design for an enoxaparin PK study.
 Green, B., & Duffull, S. B. (2003). Prospective evaluation of a D-optimal designed population pharmacokinetic study. Journal of pharmacokinetics and pharmacodynamics, 30(2), 145-161.